Pregabalin (Lyrica) is a medication used to treat neuropathic pain and epilepsy. It is also an effective treatment for the symptoms of generalised anxiety disorder (GAD).
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Pregabalin is the active ingredient in Lyrica, which is an anticonvulsant and anti-anxiety medication that was developed as a successor to gabapentin. It can be used alone or in combination with other medications to treat chronic health issues like nerve pain and anxiety. Due to its unique, multimodal mechanism of action, this medication is also recommended in the treatment of various other conditions.
Despite increase in popularity, a consistent and frequent question associated with this medication is - what is pregabalin used for? Although this medication is primarily approved by the FDA for the treatment of nerve pain, seizures and generalised anxiety disorder, it also has several other uses. These include treating fibromyalgia, restless leg syndrome and chronic lower back pain. The following table describes these conditions further:
|Nerve pain (also known as neuralgia or neuropathic pain)||Nerve pain is a condition that happens when a health issue causes damage to nerves that convey pain signals to the brain. This type of pain typically feels like a burning, stabbing or shooting sensation that can be mild or severe. People with this condition are often overly sensitive to pain.|
|Seizures||Seizures are caused by changes in electrical activity in the brain which may lead to symptoms such as shaking and loss of control or consciousness.|
|Generalised anxiety disorder (GAD)||Generalised anxiety disorder involves long-term worry and anxiety that is excessive and difficult for a person to control. A patient with GAD tends to be overly anxious about everyday circumstances like family, relationships, health and finances. Pregabalin anxiety medication is recommended in the treatment of GAD.|
|Fibromyalgia||Fibromyalgia is a long-term condition that is characterised by pain and tenderness throughout the body. Other symptoms include difficulty concentrating, insomnia and fatigue. Pregabalin for pain associated with fibromyalgia is usually effective.|
|Restless legs syndrome||Restless leg syndrome (RLS) involves uncomfortable urges to move the legs, particularly in the evenings. This condition is estimated to affect about 10% of adults and it can severely affect sleep, so treatment is often recommended.|
|Chronic lower back pain||Chronic lower back pain involves pain that persists for 3 months or longer, even after the injury or illness that caused it has healed. This type of pain can change from being a continuous, mild ache to a sharp, stabbing pain sensation that can be debilitating.|
Scientists are still exploring the precise MOA of how pregabalin works to treat these conditions. However, this medication is thought to induce its effects in the following ways:
Pain associated with conditions like diabetic neuropathy and fibromyalgia can reduce the quality of a person's life. It can interfere with sleep and cause difficulty for a patient when participating in daily activities. As a result, patients with chronic pain conditions often experience emotional consequences like anxiety and depression.
Healthcare providers often recommend that patients buy pregabalin to reduce pain levels and decrease their overall sensitivity to discomfort. In addition, this medication has the ability to reduce anxiety and improve sleep. This tends to be highly beneficial as it can help a patient stay in a positive frame of mind and enjoy daily activities.
The dosage of pregabalin depends on the condition being treated and it should be personalised for each patient. The usual adult pregabalin dose will vary from 150mg (half a pregabalin tablet) to 600mg (two tablets) per day, taken in 2 or 3 separate doses. The following are general recommended dosage instructions for certain health conditions:
For patients who tolerate this medication well and benefit from treatment, a maximum daily pregabalin dose of 600mg per day may be administered in two or three separate doses. This medication should be taken with some water, on a full or empty stomach.
Alcohol does not have a direct effect on the mechanism of action associated with this medication. However, it should be used with caution or avoided if you experience sleepiness or dizziness during treatment, as alcohol can make this side effect worse. Common, mild pregabalin side effects that may occur in more than 1 in 100 people include:
If you buy pregabalin, there are steps that can be taken to mitigate or prevent these side effects. Drink enough water and get sufficient sleep to help prevent headaches. It is safe to take this medication with traditional painkillers. Daytime sleepiness can be reduced by taking a lower dose and it often helps to take this medication with food if you experience nausea during treatment.
The safety of this medication has not been established during pregnancy so its use should be avoided by pregnant women. The following patients should take extra care and use a lower dose, especially at the beginning of treatment:
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